ADAMTS13: Biology and Disease by George M. Rodgers

By George M. Rodgers

This accomplished quantity discusses the protease ADAMTS13, summarizing the present prestige of easy and medical study. The 9 authoritative chapters start with a old viewpoint via exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its common functionality in hemostasis (cleavage of von Willebrand factor). rising examine issues for ADAMTS13 are lined, together with its capability position in angiogenesis and different points of cellphone biology. extra themes comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) issues examines the variations among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy reports the initial info on rising points of ADAMTS13, resembling the prestige of recombinant ADAMTS13 items and their strength utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and disorder is an important source for medical hematologists, transfusion drugs physicians, and researchers drawn to hemostasis, vascular biology, biochemistry, and metalloproteases.

Show description

Read Online or Download ADAMTS13: Biology and Disease PDF

Best hematology books

Allogeneic Stem Cell Transplantation (Current Clinical Oncology)

Across the world well-known physicians and researchers evaluate either the fundamentals of allogeneic stem cellphone transplantation and up to date advances within the box, really as they relate to antitumor results and graft-versus-host illness additionally they supply distinctive decision-tree analyses to steer clinicians in opting for and dealing with their allogeneic transplant sufferers.

Jak-Stat Signaling : From Basics to Disease

JAK tyrosine kinases and STAT transcription elements represent a signaling pathway, that is activated through cytokines. by means of activating gene transcription it regulates crucial organic responses to environmental cues. The Jak-Stat pathway is excited by the law of cellphone improvement, differentiation, proliferation and apoptosis.

Molecular Testing in Cancer

Molecular trying out in melanoma presents a cutting-edge evaluation of clinically proper molecular pathology in melanoma. The publication offers a quick, effortless to learn evaluate of often hired diagnostic molecular recommendations together with lately constructed "next iteration" analytic instruments, and provides a system-based run-through of the application of molecular trying out in person melanoma varieties, in addition to reviewing present markers in melanoma analysis, analysis, and administration.

Linked by Blood: Hemophilia and AIDS

Associated by way of Blood: Hemophilia and AIDS recounts the criteria accountable for the common an infection of individuals with hemophilia via Human Immunodeficiency Virus (HIV)-contaminated blood and provides a prescription for addressing the demanding situations of destiny viral epidemics. The publication describes the impression of AIDS on individuals with hemophilia, their households, and caregivers.

Additional resources for ADAMTS13: Biology and Disease

Sample text

Cooley MA, Fresco VM, Dorlon ME, Twal WO, Lee NV, Barth JL, Kern CB, Iruela-Arispe ML, Argraves WS. Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev Dyn. 2012;241(2):303–14. 23716. 61. Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem.

Dupuis LE, McCulloch DR, McGarity JD, Bahan A, Wessels A, Weber D, Diminich AM, Nelson CM, Apte SS, Kern CB. Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol. 2011;357(1):152–64. pii: S0012-1606(11)01101-8. 041. Epub 2011/07/14. 80. Dupuis LE, Osinska H, Weinstein MB, Hinton RB, Kern CB. Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves. J Mol Cell Cardiol. 2013;60:50–9. 010. 81. Dubail J, Aramaki-Hattori N, Bader HL, Nelson CM, Katebi N, Matuska B, Olsen BR, Apte SS.

43. Stupka N, Kintakas C, White JD, Fraser FW, Hanciu M, Aramaki-Hattori N, Martin S, Coles C, Collier F, Ward AC, Apte SS, McCulloch DR. Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. J Biol Chem. 2013;288(3):1907–17. 429647. Epub 2012/12/13. 44. Gerhardt S, Hassall G, Hawtin P, McCall E, Flavell L, Minshull C, Hargreaves D, Ting A, Pauptit RA, Parker AE, Abbott WM. Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteinerich domains.

Download PDF sample

Rated 4.81 of 5 – based on 24 votes

admin