By Hubert Schrezenmeier, Andrea Bacigalupo
This ebook takes account of the latest findings in laboratory study and scientific trials to supply a entire and updated reference at the pathophysiology, epidemiology, prognosis and remedy of got and inherited aplastic anemia. in addition to supplying a close evaluate of the pathophysiology of the ailment, the overseas group of authors covers all facets of administration, together with the proven methods of bone marrow transplantation and immunosuppressive remedy, new techniques akin to using hematopoietic development components and escalated immunosuppression, and arguable matters reminiscent of stem mobile transplantation. additionally integrated is a vital foreign consensus rfile on remedy, and a last part concentrates at the inherited syndrome Fanconi's anemia. unique therapy guidance are given, making this the definitive source for hematologists and different clinicians enthusiastic about the administration and supportive care of sufferers with aplastic anemia. Scientists drawn to bone marrow failure also will locate this a useful reference.
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Extra resources for Aplastic Anemia: Pathophysiology and Treatment
P. and Jacobsen, S. E. W. (1996) The ﬂt-3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34ϩ bone marrow progenitor cell in vitro. Blood, 87, 1317–25. de Sauvage, F. , Hass, P. , Spencer, S. , Malloy, B. , Gurney, A. , Spencer, S. , Cytokine abnormalities in aplastic anemia Darbonne, W. , Henzel, W. , Wong, S. , Kuang, W. , Oles, K. , Solberg, L. , Goeddel, D. V. and Eaton, D. L. (1994) Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
Although a decrease in the plasma GCSF concentration was observed in all patients who achieved self-sustaining hemopoiesis following BMT or immunosuppressive therapy, it was lower in patients undergoing BMT as compared with those receiving immunosuppressive therapy for any given degree of neutropenia. Thrombopoietin (TPO) TPO is a cytokine that supports megakaryocyte colony formation, increases megakaryocyte size and ploidy, and is the most important regulator of platelet production (Kaushansky, 1995).
1995b) have demonstrated elevated plasma/serum levels of ﬂt-3L in a small number of patients with acquired AA. Recently, Wodnar-Filipowicz et al. (1996) studied circulating levels of ﬂt-3L in 34 patients with AA using ELISA. At diagnosis, ﬂt-3L levels were highly elevated in patients with AA compared with normal controls, 2653 Ϯ 353 pg/ml versus 14 Ϯ 39 pg/ml. Flt-3L levels returned to near normal levels within the ﬁrst 3 months following BMT or successful immunosuppressive therapy (100 Ϯ 31 and 183 Ϯ 14 pg/ml, respectively).