By Herbert Begemann
-Enhanced sixth variation includes extra illustrations and documented figures
-A ideal reference for hematological and oncological departments and the clincal labortory
-Classified findings from the area health and wellbeing Organization
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Band form. Segmented neutrophil. Lymphocyte. Tissue basophil. 5 2 9 7 Ii IS " .. ' 28 29 41 Fig. 9. Eosinophil and basophil granulocytes, toxic granulation of leukocytes, Pelger nuclear anomaly, Alder's anomaly -1,250 x Eosinophil granulocytes (cells 1-9) develop in the same way as the neutrophils. They can with certainty be distinguished from these from the myelocyte stage. However the typical eosinophil granulation is partly observed in the promyelocyte stage already and according to Undritz, also in myeloblasts.
Furthermore, sizable vacuoles are seen in myeloblasts and myelocytes in which a large round inclusion is recognizable. Phase contrast and electron microscopy allow discerning coarse cytoplasmic inclusions whose structure is remarkably polymorphous in neutrophil and eosinophil granulocytes, lymphocytes, but also in erythroblasts. Further findings indicate that the disease is due to a defect of the lysosome membrane. This pathogenetic disorder, which predominantly affects biochemically glycolipids, acts not only on blood cells but also on other organs, so that this anomaly can by no _means be considered to be benign.
LOd). It has been observed during prolonged treatment with chloramphenicol, in phenylketonuria, and in diabetes mellitus; but it also appears during severe bacterial and viral infections. It is the expression of a disturbed oxygen metabolism in the affected cells. Undritz maintains that these vacuoles contain a proteinlike substance. Figs. lOa-d. Cytochemistry and toxic changes of leukocytes. Anomalous granulation (a) PAS reaction of peripheral blood cells. Positive segmented nuclei (right) and negative monocyte.