Bacterial Stress Responses by Gisela Storz, Regine Hengge

By Gisela Storz, Regine Hengge

Gain new perception on using bacterial rigidity responses to higher strive against bacterial an infection with antibiotics and enhance biotechnology.

  • Reviews the gigantic variety of new findings that experience vastly complicated the certainty of bacterial rigidity responses some time past 10 years.
  • Explores basic regulatory ideas, together with the most recent findings from genomics stories, together with new examine findings on either particular and normal pressure responses.
  • Details how rigidity responses impact the interactions among micro organism and host cells and covers bacterial tension responses in several niches and groups, with an emphasis on severe environments.

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2007]) taking the place of Y. For example, an FFL with sRNA was recently identified in the osmolarity-sensing mechanism of E. , 2007). Under high osmolarity, OmpR activates transcription of the sRNA, MicF, which represses the translation of the porin-coding gene ompF. OmpR also directly regulate the transcription of ompF as an activator at low levels and a repressor at high levels (Slauch and Silhavy, 1996) (iii) Single input module. This network motif is characterized by a regulator X that regulates a group of target genes.

2009b. Regulatory integration of horizontallytransferred genes in bacteria. Front. Biosci. 14:4103–4112. , M. Fookes, A. Ivens, M. W. Mangan, J. Wain, and C. J. Dorman. 2007. An H-NS-like stealth protein aids horizontal DNA transmission in bacteria. Science 315:251–252. Foster, P. L. 2007. Stress-induced mutagenesis in bacteria. Crit. Rev. Biochem. Mol. Biol. 42:373–397. , V. Jimenez-Jacinto, M. Peralta-Gil, A. SantosZavaleta, M. I. Penaloza-Spinola, B. Contreras-Moreira, J. Segura-Salazar, L. Muniz-Rascado, I.

Thus, this motif allows continued production of the output genes upon a transient loss of the input signal. This behavior was experimentally demonstrated in the flagella system of E. coli with a delay of about an hour upon SX removal, potentially protecting CHAPTER 2 • ARCHITECTURE AND DYNAMICS 23 Figure 3. Functional properties of the C1-FFL motif. (a) C1-FFL with an AND gate input function as a sign-sensitive delay element and a persistence detector. Z is activated with a delay because it starts to accumulate only when Y crosses its activation threshold for Z.

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