Bacteriophages: Biology and Applications by Alexander Sulakvelidze, Elizabeth Kutter

By Alexander Sulakvelidze, Elizabeth Kutter

Based on the emergence of pathogenic micro organism that can not be taken care of with present antibiotics, many researchers are revisiting using bacteriophages, or phages, to struggle multidrug-resistant micro organism. Bacteriophages: Biology and functions offers unprecedented, entire info on bacteriophages and their purposes, comparable to phage treatment. It deals ideas, media, and technique keen on keeping apart and dealing with healing phages. images, line drawings, and electron micrographs of phages also are incorporated. With its vast process, this publication is an invaluable reference for microbiologists, hematologists, and infectious disorder researchers.

Show description

Read Online or Download Bacteriophages: Biology and Applications PDF

Similar hematology books

Allogeneic Stem Cell Transplantation (Current Clinical Oncology)

The world over well-known physicians and researchers assessment either the fundamentals of allogeneic stem mobile transplantation and up to date advances within the box, really as they relate to antitumor results and graft-versus-host disorder additionally they supply specific decision-tree analyses to lead clinicians in deciding on and handling their allogeneic transplant sufferers.

Jak-Stat Signaling : From Basics to Disease

JAK tyrosine kinases and STAT transcription components represent a signaling pathway, that's activated via cytokines. via activating gene transcription it regulates crucial organic responses to environmental cues. The Jak-Stat pathway is keen on the legislation of phone improvement, differentiation, proliferation and apoptosis.

Molecular Testing in Cancer

Molecular checking out in melanoma offers a cutting-edge overview of clinically suitable molecular pathology in melanoma. The publication presents a short, effortless to learn evaluate of quite often hired diagnostic molecular concepts together with lately constructed "next iteration" analytic instruments, and provides a system-based run-through of the software of molecular checking out in person melanoma varieties, in addition to reviewing present markers in melanoma prognosis, diagnosis, and administration.

Linked by Blood: Hemophilia and AIDS

Associated by means of Blood: Hemophilia and AIDS recounts the standards accountable for the frequent an infection of individuals with hemophilia by means of Human Immunodeficiency Virus (HIV)-contaminated blood and provides a prescription for addressing the demanding situations of destiny viral epidemics. The ebook describes the effect of AIDS on individuals with hemophilia, their households, and caregivers.

Extra info for Bacteriophages: Biology and Applications

Sample text

1. 2. 3. 4. 8. 1. 1. THE NATURE OF BACTERIOPHAGES As discussed throughout this book, bacteriophages are viruses that only infect bacteria. They are like complex spaceships (Fig. 1), each carrying its genome from one susceptible bacterial cell to another in which it can direct the production of more phages. Each phage particle (virion) contains its nucleic acid genome (DNA or RNA) enclosed in a protein or lipoprotein coat, or capsid; the combined nucleic acid and capsid form the nucleocapsid. The target host for each phage is a specific group of bacteria.

These results, taken together, have been idealized as a textbook case, taken to show “that only the DNA of phage entered the host bacteria. Their surrounding protein coats remained outside and thus could be ruled out as potential genetic material” (Watson, Gilman, Witkowski, and Zoller, 1992, p. 16–17). , f29 which has protein attached to its DNA and which enters the cell upon infection). While the HersheyChase experiment (sometimes known as “the blender experiment”) has been taken as the final “proof ” that DNA is the genetic material, Alfred Hershey apparently expected the protein of the phage to play a role in the genetic process, right up to the time of these experiments (Szybalski, 2000).

In addition to the parental-to-progeny label transfer experiments previously 20 Bacteriophages: Biology and Applications described, soon a novel DNA base, 5-hydroxymethylcytosine, was discovered in the DNA of the T-even phages (Wyatt and Cohen, 1953). Inhibitors of protein synthesis (amino acid analogues and antibiotics) were observed to block the intracellular development of phage, which was strong evidence that new protein synthesis was needed as part of the process of phage reproduction. , the coat that could be detected antigenically late in the infectious cycle).

Download PDF sample

Rated 4.40 of 5 – based on 48 votes

admin