Bacteriophages: Biology and Applications by Alexander Sulakvelidze, Elizabeth Kutter

By Alexander Sulakvelidze, Elizabeth Kutter

Based on the emergence of pathogenic micro organism that can not be taken care of with present antibiotics, many researchers are revisiting using bacteriophages, or phages, to struggle multidrug-resistant micro organism. Bacteriophages: Biology and functions offers unprecedented, entire info on bacteriophages and their purposes, comparable to phage treatment. It deals ideas, media, and technique keen on keeping apart and dealing with healing phages. images, line drawings, and electron micrographs of phages also are incorporated. With its vast process, this publication is an invaluable reference for microbiologists, hematologists, and infectious disorder researchers.

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Extra info for Bacteriophages: Biology and Applications

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1. 2. 3. 4. 8. 1. 1. THE NATURE OF BACTERIOPHAGES As discussed throughout this book, bacteriophages are viruses that only infect bacteria. They are like complex spaceships (Fig. 1), each carrying its genome from one susceptible bacterial cell to another in which it can direct the production of more phages. Each phage particle (virion) contains its nucleic acid genome (DNA or RNA) enclosed in a protein or lipoprotein coat, or capsid; the combined nucleic acid and capsid form the nucleocapsid. The target host for each phage is a specific group of bacteria.

These results, taken together, have been idealized as a textbook case, taken to show “that only the DNA of phage entered the host bacteria. Their surrounding protein coats remained outside and thus could be ruled out as potential genetic material” (Watson, Gilman, Witkowski, and Zoller, 1992, p. 16–17). , f29 which has protein attached to its DNA and which enters the cell upon infection). While the HersheyChase experiment (sometimes known as “the blender experiment”) has been taken as the final “proof ” that DNA is the genetic material, Alfred Hershey apparently expected the protein of the phage to play a role in the genetic process, right up to the time of these experiments (Szybalski, 2000).

In addition to the parental-to-progeny label transfer experiments previously 20 Bacteriophages: Biology and Applications described, soon a novel DNA base, 5-hydroxymethylcytosine, was discovered in the DNA of the T-even phages (Wyatt and Cohen, 1953). Inhibitors of protein synthesis (amino acid analogues and antibiotics) were observed to block the intracellular development of phage, which was strong evidence that new protein synthesis was needed as part of the process of phage reproduction. , the coat that could be detected antigenically late in the infectious cycle).

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