Bioactive Compounds from Extremophiles: Genomic Studies, by Lesley-Ann Giddings, David J. Newman

By Lesley-Ann Giddings, David J. Newman

​This SpringerBrief sheds new gentle on bioactive fabrics from extremophiles with the focal point at the biosynthesis strategies and similar genomics. It bargains with all features of the chemical substances produced by way of organisms residing less than severe stipulations that could have capability as medications or result in novel medicinal drugs for human use.

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Additional resources for Bioactive Compounds from Extremophiles: Genomic Studies, Biosynthetic Gene Clusters, and New Dereplication Methods

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2001) (continued) Scott et al. (2008), Oh et al. (2009) Oh et al. (2009) Iwasaki et al. (1984), PartidaMartinez and Hertweck (2005, 2007) Kupchan et al. (1972), Wings et al. (2013) References Imada et al. (2002) Iwasaki et al. (1984), PartidaMartinez and Hertweck (2005, 2007) Cunningham et al. (1950), Bentley et al. (1951), Sakurai and Masuda (2013), Tuli et al. (2014) 2 Activating the Expression of Natural Product Biosynthetic Gene Clusters 25 N/A information not available Cocultures of Emericilla sp.

11) from the intractable mixture of the cyanobacterium Lyngbya bouillonii associated with heterotrophic eubacteria (Grindberg et al. 2011). Both metagenomic sequencing and single-celled genomics have also been used to identify the true producers of bioactive metabolites isolated from sponges.  11) and the 48 residue ribosomal peptide polytheonamides, were thought to be solely produced by the sponge; however, challenges were encountered when trying to reisolate these bioactive molecules. To address this challenge, Wilson and coworkers used single-celled analysis to examine the microbial consortium associated with Theonella swinhoei-type yellow (Y) (Wilson et al.

Tyson and coworkers also used a combination of whole-genome shotgun sequencing and PCR-based rRNA analyses to determine the composition and function of simpler microbial communities in samples collected from acid mine drainage biofilm collected in the Richmond mine at Iron Mountain, CA, USA (Tyson et al. 2004). The simple community structure enabled nearly complete genomes of Leptospirillum group II and Ferroplasma type II organisms to be constructed, providing insight into how each organism depends on each other to obtain carbon or nitrogen and maintains a neutral intracellular pH in a highly acidic, metal-rich environment.

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