Blood Smears Reinterpreted by Marcel Bessis

By Marcel Bessis

The translation of Blood Smears Reinterpreted was once all started while the French unique used to be nonetheless present process revisions. i used to be accorded the oppor­ tunity to question any assertion or flip of word that was once doubtful to me or seemed susceptible to misinterpretation. it truly is my wish that hence, ambiguities-particularly these inherent in changes among American and ecu ropean usage-have been got rid of and i have at the very least ap­ proached the last word aim of any translation: to mirror the author's purpose thoroughly whereas last as readable because the unique. past the function of translator, i used to be inspired to imagine the function of critic. hence, a few pages or perhaps unmarried sentences have been hotly debated, occasionally for hours, as Marcel Bessis insisted that any inter­ pretations on which shall we now not agree will be so indicated. in truth our dialogue consistently led to contract, notwithstanding they ended in adjustments of a sentence right here or a observe there and, from time to time, to the addition of a footnote or a short paragraph.

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Note the characteristic maturation of nuclear chromatin idero me Fig . 3 - The number of ribosomes decreases while the amount of hemoglobin increases 31 4 - Polychromatophilic Normoblasts I and II (E4 and E5 ) Definition These stages of red cell development are defined by the increasing acidophllia of the cytoplasm In Glemsa-stalned smears due to the increasing concentration of hemoglobin. Smears E. IS smaller than E3 and E. IS smaller than E•. The volume of the nucleus diminishes more rapidly than that of the cytoplasm and at the end of the E.

I ,l ## -- .. I ,, _.. "," Fig. 2- Theoretical model of differentiation of blood cells. All cells in the grey area at left are hypothetical: (I) Totipotential stem cell; (II) pluripotential hemopoietic stem cell; (III) lymphoid stem cell: (IV-X) stem cells committed to differentiation into specific lines 19 9 - Amplification and Maturation Maturation of the different cell lines follows basIcally analogous laws of development. The development of the erythrocytic and thrombocytic series Illustrates the analogy between two cell lines In which the maturation appears on first sight qUite different.

176). The cytoplasm is a uniform blue with very few colorless areas. The centrosome IS seldom recognizable. Mitoses of Normoblasts (E, to E4 ) Mitoses are frequently seen In normal bone marrow aspirates. They may exhibit some peculiar features: 1) The cytoplasmic basophilia may not be uniform but appear as fine granulations In the colorless background. On rare occasions this phenomenon may also be seen In non-dividing cells. This pecularlty is not restricted to the red cell series and may be encountered In other cell lines on rare occaSions.

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