Current Topics in Microbiology and Immunology / Ergebnisse by H. Wigzell, P. Häyry (auth.), W. Arber, R. Haas, W. Henle,

By H. Wigzell, P. Häyry (auth.), W. Arber, R. Haas, W. Henle, P. H. Hofschneider, J. H. Humphrey, N. K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H. G. Schweiger, M. Sela, L. Syruček, P. K. Vogt, E. Wecker (eds.)

Prominent development in molecular biology was once purely made whilst it grew to become attainable to split functionally designated molecules via benefiting from their biophysical houses. Likewise, the research of the services of heterosexual­ geneous populations of immunocompetent cells, as to the practical homes in their quite a few subpopulations, can't be performed till those should be remoted in kind of natural shape through selective fractionation. over the last few years major advances were made during this box, and cells were separated in line with measurement, density or cost (MILLER et aI. , 1969; SHORTMAN, 1968; ANDERSSON, 1973 c), or by way of making the most of extra particular floor markers to permit selective depletion or enrichment of a given subpopulation of cells (WIGZELL and ANDERSSON, 1971). even though separation ideas were utilized in quite a few mobile platforms, they've been relatively valuable within the learn of reticuloendothelial cells and basically within the examine of cells partici­ pating within the immune responses. really wide experiences were written which good disguise the equipment used for separation of cells and the implications acquired with some of the techniques (WIGZELL and ANDERSSON, 1971; SHORTMAN, 1972). to check this paintings is changing into a increasingly more voluminous activity. As info speedily acquire, we won't try and make any such entire review.

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Synergy among thymocyles and peripheral lymph nocle cells in the in vitro generation of lymphocytes cytotoxic to alloantigens. Trans. Proc. 5,1711-1716 (1973). TYAN, M. , NESS, D. : Modification of the mixed lymphocyte reaction with various antisera. Transplantation 13, 198-199 (1972). TWOMEY, J. , BROWN, J. , LAUGHTER, A. , JORDAN, P. : Cellular requirements for the mitotic reasponse in allogeneic mixed lymphocyte culture. J. Immunol. 104, 845-850 (1970). VITETTA, E. , UHR, J. : Cell surface immunoglobulin.

Science 172, 1350-1352 (1971 b). Decoding of Regulatory Signals at the Microbial Surface 1 ,2 JOSE L. REISSIG 3 Table of Contents 1. Introduction . . . II. Bacterial Pili and Mating . . . . . A. The Sex Pili and Genetic Transfer in E. coli B. The Sex Pili as Coliphage Receptors . . C. Is there a Specific Sex Substance on the Surface of Female E. coli ? III. Mating Substances in Yeasts ............... A. Sexual Agglutination in Hansenula wingei . . . . . B. Mating Substances in Saccharomyces and Schizosaccharomyces IV.

Thus, in 1965, KALCKAR summarized results indicating that the polymers of the external surface of a bacterium (which he named "ektopolymers") play a decisive role in determining the repertoire of its social activities. Until very recently interest in the "ektobiology" of microorganisms-social or regulatory-has been limited, but a reversal of this neglect is now evident (see, for instance, TOMAsz, 1971). Two factors are probably significant in this reversal. One is the extent of our current understanding of the molecular biology of nucleic acids in microorganisms, which may approach saturation in some areas.

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