Death Receptors and Cognate Ligands in Cancer by Harald Wajant (auth.), Holger Kalthoff (eds.)

By Harald Wajant (auth.), Holger Kalthoff (eds.)

Death receptors play a primary position in directing apoptosis in mammalian cells. This means of lively cellphone dying is critical for a few organic approaches, e.g. for the law of the immune process. dying receptors are cellphone floor receptors that transmit apoptotic indications initiated by way of corresponding dying ligands. Many advanced signaling pathways are activated and apoptosis is the ultimate results of a posh biochemical cascade of events.

Besides their position within the induction of cellphone demise, proof now exists that loss of life receptors may be able to turn on numerous non-apoptotic signaling pathways which, reckoning on mobile context, could lead on to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive development of melanoma cells.

This e-book seems to be on the molecular foundation of loss of life receptor signaling and the position of loss of life receptors in melanoma development.

Show description

Read or Download Death Receptors and Cognate Ligands in Cancer PDF

Similar microbiology books

Case Files Microbiology (3rd Edition) (Lange Case Files)

Submit 12 months notice: First released may perhaps fifth 2005


Experience with medical situations is vital to excelling at the USMLE Step 1 and shelf assessments, and eventually to offering sufferers with efficient scientific care. Case records: Microbiology offers fifty four true-to-life situations that illustrate crucial suggestions during this box. every one case comprises an easy-tounderstand dialogue correlated to crucial uncomplicated technological know-how options, definitions of key phrases, microbiology pearls, and USMLE-style overview questions.

With Case documents, you'll research rather than memorize.

• study from fifty four high-yield situations, each one with board-style questions and key-point pearls
• grasp complicated suggestions via transparent and concise discussions
• perform with evaluate inquiries to toughen learning
• Polish your method of medical problem-solving
• excellent for clinical and dental scholars getting ready for direction assessments and the forums

T-Cell Trafficking: Methods and Protocols

Within the final decade, plenty of significant discoveries have make clear the molecular mechanisms of lymphocyte migration and the anatomy of immune responses. In T-Cell Trafficking: tools and Protocols, professional researchers discover how the advance of novel and state of the art concepts, relatively within the box of real-time imaging and genetic manipulation, have ended in an elevated realizing of lymphocyte trafficking.

Handbook of Chlor-Alkali Technology: Volume I: Fundamentals, Volume II: Brine Treatment and Cell Operation, Volume III: Facility Design and Product Handling, ... Developments (Developments in Hydrobiology)

Foreword:- it really is mind-blowing that we needed to wait goodbye for a brand new ebook that provides a finished therapy of chlor-alkali production know-how. Technologists are mostly nonetheless making do with the classical e-book edited by means of Sconce, yet that's greater than thirty years outdated. on the time of its e-book, steel anodes have been simply commencing to look, and ion-exchange membrane know-how used to be constrained to laboratories.

Plant Surface Microbiology

Such a lot vegetation strongly depend upon the co-existence with microorganisms: either teams make the most of those symbioses. it's been proven that a huge variety of particular genes in vegetation and microorganisms are just activated in the course of those interactions. after all, quite a few microbes additionally act as pathogens. Interactions among crops and microorganisms are frequently situated on plant surfaces, akin to leaf cuticles, seeds and customarily at the roots.

Additional resources for Death Receptors and Cognate Ligands in Cancer

Example text

Receptor internalization is both actin and caspase dependent, indicating a feed-forward mechanism by which caspase-8 activity can enhance its own cleavage. The internalized receptor is then targeted to an endosomal pathway, since it colocalizes with the transferrin receptor (Algeciras-Schimnich et al. 2002). Internalization and capping occur more rapidly and prominently in Type I cells which correlates with more rapid DISC activation (Algeciras-Schimnich and Peter 2003; Eramo et al. 2004; Siegel et al.

In one instance, cell death is promoted through dissolution of receptor-associated signaling (TNFR1), while in another apoptosis is abrogated due to inefficient formation 32 M. Ramaswamy et al. of a signaling complex (Fas). As a result, lipid raft associated signaling has two very distinct outcomes in TNFR1 and Fas. Fas signaling should be seen as more of a dynamic process that involves more than just ligand binding to receptor, and that which also takes into account local microenvironment, subcellular localization, secondary modifications of Fas and global cell signaling pathways.

S-palmitoylation is a reversible modification involving addition of a 16-carbon palmitate moiety to a cysteine residue via a thioester linkage, and can be readily cleaved by palmitoyl thioesterases. An interesting feature of S-palmitoylation is its dynamic nature: cycles of palmitoylation and depalmitoylation occur in a regulated fashion for many proteins, allowing for translocation in and out of lipid raft microdomains (Resh 2006). Fas is palmitoylated at cysteine 199, just proximal to the cytoplasmic juxamembrane region (Chakrabandhu et al.

Download PDF sample

Rated 4.32 of 5 – based on 32 votes