By Mark A. Crowther, Jeffrey Ginsberg, Holger Sch?nemann, Ralph M. Meyer, Richard Lottenberg
This distinct new booklet makes use of a chain of focussed questions, finished literature reviews and dependent grades of advice to supply facts for the therapy of hematological problems, either malignant and benign. With contributions from prime foreign specialists who've a true realizing of evidence-based drugs the booklet offers accomplished stories followed by means of medical commentaries and proposals at the top therapy regimes to undertake for person patients.
The ebook is divided into sections: the 1st examines the technique underlying proof dependent perform, and the second one concentrates at the scientific perform of hematology, offering present “best facts” to steer perform in a sequence of well-defined scientific situations.
This scientific reference is a useful resource of evidence-based info distilled into suggestions for scientific perform on the way to be welcomed by means of practitioners, trainees and linked healthiness professionals.Content:
Chapter 1 ranking the standard of facts and Making techniques: A advisor to the Spectrum of medical study (pages 1–9): Holger J. Schunemann, Martin Stanulla, Jan L. Brozek and Gordon G. Guyatt
Chapter 2 an summary of Systematic experiences (pages 10–14): Martin Prins, Arina ten Cate?Hoek and Pieter Leffers
Chapter three studying ends up in scientific study: review of Measures of influence, Measures of Precision, and Measures of Diagnostic Accuracy for Clinicians and Researchers (pages 15–22): Marcello Di Nisio, Harry R. Buller and Patrick M. M. Bossuyt
Chapter four discovering the facts in Hematology (pages 23–31): okay. Ann McKibbon, Cynthia J. Walker?Dilks and R. Brian Haynes
Chapter five making use of EBM in medical perform (pages 32–36): Alessandro Squizzato, Walter Ageno and Davide Imberti
Chapter 6 utilizing facts to steer the prognosis of affliction (pages 37–45): Lucas M. Bachmann and Holger J. Schunemann
Chapter 7 prognosis of Deep Vein Thrombosis (pages 47–55): Lori?Ann Linkins
Chapter eight The prognosis of Acute Pulmonary Embolism (pages 56–64): Victor F. Tapson
Chapter nine preliminary remedy of Deep Vein Thrombosis and Pulmonary Embolism (pages 65–72): Sam Schulman
Chapter 10 Long?Term Anticoagulation in Venous Thromboembolism (pages 73–87): Clive Kearon
Chapter eleven Thrombolytic treatment for Deep Vein Thrombosis and Pulmonary Embolism (pages 88–98): Simon J. McRae and John W. Eikelboom
Chapter 12 Inferior Vena Cava Interruption (pages 99–109): Michael B. Streiff and Christine L. Hann
Chapter thirteen administration of Venous Thromboembolism in being pregnant (pages 110–119): Wee?Shian Chan
Chapter 14 Pediatric Thrombosis (pages 120–123): Anthony ok. C. Chan and Paul Monagle
Chapter 15 Bridging Anticoagulation in sufferers Who Require transitority Interruption of Warfarin for surgical procedure (pages 124–130): James D. Douketis and Scott Kaatz
Chapter sixteen Evidence?Based method of the analysis and administration of Thrombotic Thrombocytopenic Purpura (pages 131–137): Brian Boulmay and Craig S. Kitchens
Chapter 17 analysis and administration of Disseminated Intravascular Coagulation (pages 138–144): Julia A. M. Anderson
Chapter 18 analysis and administration of Hereditary Bleeding problems: together with Congenital/Acquired Platelet functionality problems (pages 145–151): Nigel S. Key and Alice D. Ma
Chapter 19 prognosis and administration of got Bleeding problems: nutrition ok Antagonists (pages 152–157): Miguel A. Escobar
Chapter 20 prognosis and administration of Heparin?Induced Thrombocytopenia (pages 158–167): Theodore E. Warkentin and Andreas Greinacher
Chapter 21 administration of Antiphospholipid Antibody Syndrome (pages 168–175): Wendy Lim and Mark A. Crowther
Chapter 22 medical Questions in Iron Overload (pages 177–188): Antonello Pietrangelo and Nicola Magrini
Chapter 23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and natural pink mobile Aplasia (pages 189–196): Shivani Srivastava and Richard W. Childs
Chapter 24 received Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia (pages 197–205): Marc S. Zumberg and Marc J. Kahn
Chapter 25 Immune Thrombocytopenic Purpura (pages 206–214): James N. George, Sara okay. Vesely and George R. Buchanan
Chapter 26 Neutropenia (pages 215–220): David C. Dale
Chapter 27 Hypereosinophilia: fundamental and Secondary (pages 221–228): Florence Roufosse, Michel Goldman and Elie Cogan
Chapter 28 Porphyrias (pages 229–237): Gagan Sood and Karl E. Anderson
Chapter 29 Membrane and Enzyme Abnormalities of the Erythrocyte (pages 238–243): Patrick G. Gallagher and Ernest Beutler
Chapter 30 Sickle telephone illness (pages 244–250): Richard Lottenberg and Sally C. Davies
Chapter 31 Evidence?Based therapy of Thalassemia significant (pages 251–259): Issac Odame and Deborah Rund
Chapter 32 Acute Lymphoblastic Leukemia in Adults (pages 261–267): Stephen Couban and Andrea Kew
Chapter 33 Acute Myeloid Leukemia in Adults: Remission Induction remedy (pages 268–277): Cara A. Rosenbaum and Richard A. Larson
Chapter 34 Acute Myeloid Leukemia in Adults: Postremission treatment (pages 278–286): Cara A. Rosenbaum and Richard A. Larson
Chapter 35 present components of Controversy within the therapy of sufferers with Newly clinically determined Acute Promyelocytic Leukemia (pages 287–293): Martin S. Tallman and Syed A. Abutalib
Chapter 36 continual Lymphocytic Leukemia (pages 294–299): Bruce D. Cheson
Chapter 37 persistent Myeloid Leukemia (pages 300–304): Irwin Walker
Chapter 38 chosen administration of sufferers with Myelodysplastic Syndromes (pages 305–310): John M. Storring and Karen W. L. Yee
Chapter 39 Evidence?Based remedy of Burkitt Lymphoma in Adults (pages 311–316): John Gerecitano and David J. Straus
Chapter forty basic vital worried process Lymphoma (pages 317–326): Tamara Shenkier
Chapter forty-one Diffuse huge B?Cell Lymphoma (pages 327–333): Michael Crump
Chapter forty two Follicular Lymphoma (pages 334–341): Kevin Imrie and Matthew Cheung
Chapter forty three Lymphoblastic Lymphoma (pages 342–346): Tyler Y. Kang and John W. Sweetenham
Chapter forty four Mantle telephone Lymphoma (pages 347–351): C. Tom Kouroukis
Chapter forty five administration of sufferers with Peripheral T?Cell Lymphoma (pages 352–364): Kerry J. Savage
Chapter forty six chosen administration problems with sufferers with Hodgkin Lymphoma (pages 365–371): Ralph M. Meyer
Chapter forty seven Lymphocyte principal Hodgkin Lymphoma (pages 372–377): Brandon McMahon and Jonathan W. Friedberg
Chapter forty eight administration of sufferers with crucial Thrombocythemia (pages 378–384): Guido Finazzi, Giovanni Barosi and Tiziano Barbui
Chapter forty nine administration of sufferers with Polycythemia Vera (pages 385–389): Guido Finazzi, Roberto Marchioli and Tiziano Barbui
Chapter 50 Evidence?Based overview of treatments in a number of Myeloma (pages 390–395): Michael Sebag and A. Keith Stewart
Chapter fifty one administration of Waldenstrom's Macroglobulinemia (pages 396–401): Christine I. Chen
Chapter fifty two The function of Hematopoietic development components in handling sufferers with Hematologic Malignancies (pages 402–411): Heloisa P. Soares, Ambuj Kumar, Charles Bennett and Benjamin Djulbegovic
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Extra resources for Evidence-Based Hematology
For a better discussion on the merits of combined treatment with aspirin and clopidogrel, you print a copy of the article and a copy of its synopsis published in the ACP Journal Club (11). Clinical question In patients who have experienced a noncardioembolic stroke, does the combination of clopidogrel and aspirin, compared with aspirin alone, reduce the risk of cardiovascular events and does it have at least the same safety profile? practice. , proper randomization, concealment of allocation, blinding of patients and investigators, analysis of results according to the intention-to-treat principle, and percentage of patients lost to follow-up).
Totowa, NJ: Humana Press; 2005. 8 Gerstein HC, Haynes RB. Evidence-based diabetes care. Hamilton: BC Decker; 2001. 9 BMJ Clinical Evidence [online database]. London: BMJ Publishing Group [2008 Feb 12]. jsp. 10 UpToDate [online database]. Waltham, MA [2008 Feb 12]. com/ 11 Physicians’ Information and Education Resource (PIER) [online database]. Philadelphia: American College of Physicians [2008 Feb 12]. html 12 FIRSTConsult [online database]. Oxford: Elsevier [2008 Feb 12]. Ref [online database].
12 The ESPRIT Study Group. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet. 2006;367:1665–73. 13 Decousus H, Leizorovicz A, Parent F, et al. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med 1998;338:409–16. 14 Barritt DW, Jordan SC. Anticoagulant drugs in the treatment of pulmonary embolism: a controlled trial. Lancet.