Factors in Formation and Regression of the Atherosclerotic by Giorgio Weber (auth.), Gustav R. V. Born, Alberico L.

By Giorgio Weber (auth.), Gustav R. V. Born, Alberico L. Catapano, Rodolfo Paoletti (eds.)

Interest within the box of atherosclerosis examine has broadened lately. but the major concentration continues to be at the physiopathology of the arterial wall and on its interplay with blood ingredients. the aim of this NATO complicated learn Institute on "Factors in Formation and Regression of the Atherosclerotic Plaque" used to be to debate the subsequent issues: a) The physiopathology of the arterial wall; b) Animal versions; c) tools of learning the development and regression of atherosclerotic lesions quantitatively; d) The position of lipoproteins, platelets, smoke, alcohol, and so on. within the formation of atherosclerotic lesions; e) The pharmacological and nutritional keep watch over of "risk factors." This quantity is a set of the main correct shows on those subject matters. we are hoping it is going to offer a heritage for younger scientists in addition to a stimulus for additional study to biologists and clinicians. we want to recognize the aid of NATO and the meals beginning of Italy in organizing this complicated research Institute.

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However, elastin is not a prominent component of most human lesions, and despite elegant studies on the composition, crystalline form and microscopic architecture of calcium deposits (30,31) there seems to be very little information on the factors that lead to deposition of massive plates of hard calcium in atherosclerotic lesions. Calcium deposition is not necessarily linked to lipid deposition (30), but it is not clear to what extent lipids are a factor in the specific deposition of calcium in lesions.

40. 41. 42. 43. 44. 45. 46. 47. M. L. Swain and K. Cherian, Increased vascular collagen and elastin synthesis in experimental atherosclerosis in the rabbit, Atherosclerosis, 35: 11 (1980). U. Langness and S. Udenfriend, Collagen proline hydroxylase activity and anaerobic metabolism, in, "Biology of the Fibroblast", E. Kulonen and J. , Academic Press, New York, 373 (1973). R. Schwarz, L. Colarusso and P. , 102: 63 (1976). G. A. Ehrhart, Increased arterial collagen synthesis in experimental canine atherosclerosis, Atherosclerosis, 19: 13 (1974).

ELSPETH B. SMITH C. DeDuve and H. Beaufay, Tissue fractionation studies: 10. , 73: 610 (1959). L. M. , 38: 556 (1965). B. H. , 1: 119 (1976). B. Smith and LB. Massie, Destruction of endogenous low density lipoprotein in incubated intima, Atherosclerosis, 26: 427 (1977). C. J. S. J. 137: 387 (1974). A. , 10: 511 (1978). J. L. Acta, 424: 422 (1976). B. S. Slater, Relationship between low density lipoprotein in aortic intima and serum lipid levels, Lancet i, 463 (1972). B. , 12: 1 (1974). B. M. C.

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