Genetics of Bacterial Polysaccharides by Joanna B. Goldberg

By Joanna B. Goldberg

Bacterial floor or secreted polysaccharides are molecules which can functionality as obstacles to guard bacterial cells opposed to environmental stresses, in addition to act as adhesins or popularity molecules. occasionally, those molecules are immunodominant antigens eliciting a full of life immune reaction, whereas in different circumstances the expression of polysaccharides camouflages the micro organism from the immune procedure. until eventually lately, such a lot experiences at the enzymatic steps and legislation of those molecules have been played at the enteric gram adverse micro organism Escherichia coli and Salmonella typhimurium. With the arrival of recent bacterial genetics, options similar to building and characterization of polysaccharide mutants, cloning of genes and complementation of those mutations, and expression of polysaccharides in heterologous bacterial hosts has triggered investigations into the jobs and features of those molecules for lots of diverse bacteria.Here, we current the genetic research of polysaccharides from a few micro organism pathogenic to people and one symbiotic with crops in hopes that similarities within the experimental techniques in addition to discovering s from such investigations could lead to a basic realizing of polysaccharide synthesis and law in a number of micro organism. positive factors

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Zielinski, N. , and Chakrabarty, A. M. Purification and characterization of phosphomannomutase/phosphoglucomutase from Pseudomonas aeruginosa involved in the biosynthesis of both alginate and lipopolysaccharide, Journal of Bacteriology, 176, 4851-4857, 1994. 86. , and Germanier, R. Role of lipopolysaccharide in virulence of Pseudomonas aeruginosa, Infection and Immunity, 44, 508-513, 1984. 87. Holloway, B. , and Tummler, B. Genomic mapping of Pseudomonas aeruginosa PAO, Microbiology, 140, 2907-2929, 1994.

The serotype O:15 type strain IP614 is a biotype 4 strain (G. Wauters, personal communication), and since biotype 4 includes only serotype O:3 strains, it is likely that IP614 is a rough mutant of serotype O:3. The phage sensitivity of IP614 (obtained from G. 3, M. Skurnik, unpublished). , it is a rough strain missing the homopolymeric O-antigen but expressing the complete core. Y. enterocolitica serotype O:8 LPS O-antigen gene cluster of Y. enterocolitica O:8 Structure and biosynthesis of O:8 O-antigen The structure of the O-antigen repeat unit of Y.

Denlinger, L. , and Bertics, P. J. Lipopolysaccharide and bacterial virulence, in J. A. Roth, C. A. Bolin, K. A. Brogden, F. C. Minion, and M. J. ), Virulence Mechanisms of Bacterial Pathogens, Second edition, pp. 173-194. : ASM Press, 1995. 0021/ch01/frame Page 19 Thursday, September 6, 2007 2:07 PM Chapter one: Genetics of Pseudomonas aeruginosa polysaccharides 19 52. , Richards, J. , and Lam, J. S. Structural elucidation of the lipopolysaccharide core region of the O-chain deficient mutant strain A28 from Pseudomonas aeruginosa serotype O6 (International Antigenic Typing Scheme), Journal of Bacteriology, 177, 6718-6726, 1995.

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