Hematology - Science and Practice by C. Lawrie

By C. Lawrie

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Additionally, the examination of genome-wide methylation profiles of the mouse hematopoietic system demonstrated methylation pattern changes during differentiation resulting in the activation of silent genes and the silencing of active genes. , 2010) in line with the findings from the Dnmt1 deletion studies. , 2007). , 2006). 2 Histone modification Another crucial epigenetic mechanism is the posttranslational modification of histones, which embraces acetylation, methylation, phosphorylation and sumoylation among others.

2008). , 2008). , 2008). , 2008). , 2008). , 2005). , 2010). , 2009). , 2010). , 2007). Concerning the function of single miRNAs during lymphopoiesis only few data are available, despite the astonishing effects of Dicer deletion on lymphoid development. However, one study partially explains the phenotype of Dicer deletion by the defective expression of the miR17-92 cluster. This miRNA cluster that is highly expressed in progenitor cells targets the pro-apoptotic factors Bim and Pten. In line with these findings, Fig.

18081-18086. , Peschle, C. & Marziali, G. (2009). MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis. Haematologica, 94, 4, pp. 479486. J. R. (2009). Deletion of Notch1 converts proT cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cellintrinsic mechanisms. Immunity, 30, 1, pp. 67-79. C. & Geiger, H. (2010). Concise review: polarity in stem cells, disease, and aging. Stem Cells, 28, 9, pp. 1623-1629. , Cumano, A. & Geissmann, F. (2006). A clonogenic bone marrow progenitor specific for macrophages and dendritic cells.

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