By Marion E. Reid
The second one variation of The Blood team Antigen FactsBook presents key info in relation to human crimson blood phone membrane parts wearing blood workforce antigens, the molecular foundation of the antigens, their serological features, and the scientific value of blood staff antibodies. the knowledge in this crew of molecules has accelerated drastically because the prior version was once released 5 years in the past. themes contain: heritage and knowledge on terminology, expression, chromosomal project, service molecule description, molecular foundation of antigens, influence of enzymes/chemicals, medical importance, illness organization, phenotypes, glycotypes and key references.
- Over 250 absolutely up-to-date entries on blood team antigens, formatted on unmarried pages for simple use
- Inclusion of RHAG blood staff method and over twenty new antigens
- Basic technology paired with scientific purposes to offer context to information
- Full-color illustrations, gene maps and charts
- Both conventional and ISBT-sanctioned naming conventions integrated
Read or Download The Blood Group Antigen FactsBook, Second Edition (FactsBook) PDF
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Additional resources for The Blood Group Antigen FactsBook, Second Edition (FactsBook)
Dahr W. (1986) In: Recent Advances in Blood Group Biochemistry (Vengelen-Tyler, V. J. eds) American Association of Blood Banks, Arlington, VA, pp. 23–65. 9% 99% Expression Cord RBCs Altered Expressed GPB variants and on regulator type of Rhnull and on Rhmod RBCs Molecular basis associated with U antigen1 1 NH2 GPB U Val33 His Arg Phe Thr Val Pro39 RBC lipid bilayer 72 COOH 41 MNS blood group system Expression of U may require an interaction with another membrane protein, possibly the Rh associated glycoprotein (RhAG) 2,3.
1987) Biol. Chem. Hoppe-Seyler 368, 659–667. Mallinson, G. et al. (1990) Transfusion 30, 222–225. K. et al. (1986) Biochim. Biophys. Acta 884, 337–343. E. et al. (1996) Transfusion 36, 719–724. Win, N. et al. (1996) Transf. Med. 6 (Suppl. 2), 39 (abstract). 006) Henshaw Named for the first Heϩ proband, Mr. Henshaw; the original anti-He, present in a rabbit anti-M serum was identified in 1951 Occurrence Only found in Blacks: African Americans 3%; up to 7% in Natal. He(Cal) GPA(1–4*)-GPAM(5–99) * An altered sequence.
1991) Transf. Med. Rev. 5, 108–113. H. (1994) Proc. Natl. Acad. Sci. USA 91, 2415–2419. Tippett, P. et al. (1992) Transf. Med. Rev. 6, 170–182. Dahr, W. et al. (1991) Biol. Chem. Hoppe-Seyler 372, 573–584. 001) M, identified in 1927, was the first antigen of the MNS system; named after the second letter of “immune” because antiM was the result of immunizing rabbits with human RBCs Occurrence Caucasians Blacks 78% 74% Antithetical antigen N (MNS2) Expression Cord RBCs Altered 34 Expressed On some hybrid glycophorin molecules MNS blood group system Molecular basis associated with M antigen1 GPA NH2 1 Ser1 Ser Thr Thr Gly5 RBC lipid bilayer 131 COOH Nucleotide C at bp 59, G at bp 71 and T at bp 72 in exon 2 Recognition of antigen by anti-M is usually dependent on O-glycans attached to amino acid residues 2, 3 and 4.